Salicylic acid is applied directly to the area of skin affected. Assessment of methodological quality was performed. 46. Bergman R, Lowe N, Different types of allylamines or different doses were not found to have different treatment failure rates. You should not apply salicylic acid to your face because of the risk of skin irritation which may cause scarring. Federal government websites often end in .gov or .mil. Fungal infections of the feet are treated by dermatologists, general practitioners and podiatrists. Rosenberg MJ, Bell C, {"type":"entrez-nucleotide","attrs":{"text":"CD012093","term_id":"30328831","term_text":"CD012093"}}, 2 Medium term (6 weeks) treatment failure, 3 Medium term (6 weeks) treatment failure. Brown GJ, In common with the trials of allylamines versus placebo, azole creams are very much more effective than placebo, with an estimated relative reduction in treatment failure at 6 weeks of 60% (13 trials, n = 1235, RR 0.40, 95% CI 0.35 to 0.46; Analysis 2.2). The graph was moved from Analysis 12.2 'Comparisons between active treatments to Analysis12.1 'Treatments versus placebo'. Four participants in the active cream group reported mild inflammation which did not lead to discontinuation or interruption of treatment (Syed 1999). Alle BR, Kinnunen T, Combining data from 3 of the trials which had at least 80% followup (n = 685, Evans 1993b; Leenutaphong 1999; Schopf 1999) also did not show a statistically different difference in the treatment failure rates (RR 0.50, 95% CI 0.10 to 2.54; Analysis 7.2). Parish LC, Qureshi ZA, Eisen D, 18. HHS Vulnerability Disclosure, Help Brautigam M, eight rather than four weeks). Palacio A, This can lead to splits (fissures) in the skin. COMPARATIVE STUDY.sh. The ideal topical antifungal for the treatment of fungal infection should be fungicidal so that treatment can be of short duration, it should obtain high cure rates, minimise relapses, be conducive to participant compliance and have minimal adverse effects. Tolnaftate versus undecanoates Bibel DJ, Most trials achieved at least 80% followup at 6 weeks, apart from Bergstresser 1993 and Smith 1988c. Way A. We have written a published note to say that we decided to split the topic into topical and devicebased treatments for fungal infections of the toenails and topical treatments for athlete's foot, so a protocol and then a new review will be written. Metaanalysis of 11 trials comparing allylamines and azoles showed a risk ratio of treatment failure RR 0.63 (95% CI 0.42 to 0.94) in favour of allylamines. Primary outcome:Clinical cure = total signs and symptoms score of < 2. Rex IH, Tea tree oil (10%) used for 4 weeks was evaluated in 2 placebo controlled trials (n = 185, Satchell 2002; Tong 1992). Landow RK, At 4 weeks there was 100% followup, and an RR of treatment failure of 1.71 (95% CI 0.54 to 5.42; Analysis 10.3). OR / 44 47 49. 19. Rapini RP, FC ran the searches, extracted data and applied the QA tool to the additional studies. Fuente C, Comparison 2 Azoles (tx 46 weeks) vs Placebo, Outcome 3 Medium term (6 weeks) treatment failure. 1. Amorolfine 0.125, 0.25 and 0.5. Milne LJR. Bifonazole versus croconazole 3 Medium term (6 weeks) treatment failure. The ((econazole next nitrate) or ecostatin or pevaryl or tioconazole or trosyl or undecenoates or monphytol or mycota or ketoconazole or (salicylic next acid) or phytex or phytocil) Ciclopiroxolamine (1% and 0.77%) used for 4 weeks was evaluated in 2 placebo controlled trials (n = 144, Kligman 1985a; n = 317, Aly 2003). Which preparation is suitable for you will depend upon the type of skin condition you have, and the area of your body which is affected. Elewski B, Shortterm outcomes were available for all 5 trials using naftifine (n = 612) Klaschka 1984; Dobson 1989; Schachner 1990; Bagatell 1991a; Bagatell 1991b. Bergstresser PR, et al. Groppi W. Tolciclate versus miconazole: a doubleblind trial in patients with dermatomycosis, The Journal of international medical research, Sulcanazole nitrate 1% cream versus clotrimazole 1% cream in the treatment of tinea pedis. 3. Further research into the effectiveness of antifungal agents for nail infections is required. DERMATOMYCOSES Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. PLACEBO$.ti,ab. GonzalesLastra F. A clinical double blind trial comparing amorolfine cream (0.5%) with bifonazole cream 1% in the treatment of dermatomycoses. A fourth trial Pereda 2003 (n = 264) compared bifonazole 1% powder with fluconazole 1% powder and found bifonazole to produce statistically significantly fewer treatment failures (0.21, 95% CI 0.14 to 0.31; Analysis 5.2). Oliver V, The new PMC design is here! Hickman JG, Combined data for finger and toe nails, There is no definate end of treatment time from which data can be extracted, Looks at the effects on bacterial infection, not fungal infection. Ellis DH, 2. We also excluded four trials evaluating a combination of systemic and topical treatments for infected nails (Arenas 1991; Baran 2000; Barnetson 1998; Friedman 1997; Zaug 1995). A clinical trial of topical terbinafine (a new allylamine antifungal) in the treatment of tinea pedis. Bifonazole versus amorolfine Any programme of treatments administered topically to treat fungal infections of the feet compared with other treatments, placebo or no treatments. Undecanoates CABHealth and Healthstar This was useful to illustrate the range of treatment failure rates among the trials, and the amount of heterogeneity between trials and sub groups. Fungal infections of the feet normally occur in the outermost layer of the skin (epidermis). Most trials which gave detail of the adverse events experience by people participating in the trials reported burning, stinging, itching sensations. Tolnaftate Two different allylamines (naftifine 1% and terbinafine 1%) used for 1 to 4 weeks were evaluated in 11 placebo controlled randomised trials. Li Q, Overall the observed relative reduction in risk of treatment failure was 25% (RR 0.75, 95% CI 0.60 to 0.93; Analysis 1.1), although there was substantial variation in the individual study results (I2 = 79%). (#19 or #20) We handsearched podiatry journals which were not listed in the electronic databases, namely, The Foot, The Journal of British Podiatric Medicine and The Journal of the American Podiatry Association. et al. Naftifine (1%) used for 4 weeks was evaluated in 5 trials (n = 607, Bagatell 1991a; Bagatell 1991b; Dobson 1989; Klaschka 1984; Schachner 1990), a 58% relative reduction in treatment failure was observed (RR 0.42 95% CI 0.30 to 0.59; Analysis 1.2, Naftifine (tx 4 weeks) versus Placebo), with substantial variation in individual study results (I2 = 68%). Smith 1990b compared 1% naftifine once daily to twice daily both for 4 weeks (n = 101) and found fewer treatment failures with twice daily, thought the difference was not statistically significant (RR of treatment failure = 1.74, 95% CI 0.82 to 3.67; Analysis 4.2). If you buy any medicines, always check with a pharmacist that they are safe to use with your other medicines. A trial of 1% oxiconazole + fluctic used for 4 weeks versus 1% oxiconazole used for 4 weeks (n = 201, Elewski 1996) produced a statistically significant relative reduction in treatment failure of 47% (RR 0.53, 95% CI 0.33 to 0.87; Analysis 5.2), favouring oxiconazole + fluctic. Comparison 8 Allylamines 46 weeks vs Azoles 46 weeks, Outcome 3 Long term (12 weeks onwards) treatment failure. ( YEAST or SPORE or SPORES ) ti,ab,sh. No microscopy for any participant, Data combined for three sites; tinea pedis, tinea cruris, tinea corporis, Culture is used to identify pathogens at baseline but not to assess outcome, Results for mycological cure do not separate out those for tinea pedis from tinea cruris, Cannot separate tinea pedis results from those of tinea corporis and inguilalis. Stettendorf S. Treatment of onychomycosis: a randomised double blind comparison study with topical bifonazoleurea ointment alone and in combination with short duration oral griseofulvin, Miconazole therapy for endemic fungal disease. Fisher G, The following areas were addressed, since these may be associated with biased estimates of treatment effect (Juni 2001): et al. Another trial evaluated 1% bifonazole used for 3 weeks versus 1% bifonazole removed after one hour for 3 weeks (n = 73, Friederich 1992) but did not detect any difference between the rates of treatment failure (RR 4.34, 95% CI 0.51 to 37.01; Analysis 5.2). ( NYSTATIN or NYSTAFORM or NYSTAN or TINADERM or ASTEROL or DERMONISTAT ) ti,ab,sh. Longterm (12 weeks onwards): longest followup of at least 12 weeks. Twentynine trials compared a single active treatment with placebo (Akers 1989; Aly 2003; Bagatell 1986; Bagatell 1991a; Bagatell 1991b; Berman 1992; Chretien 1980; Coffey 1986; Dobson 1989; Evans 1991; Gentles 1974; Gomez 1986; Ison 1990; Izuno 1986; Klaschka 1984; Kligman 1985a; Korting 2001; Mandy 1974; Savin 1990; Savin 1994; Savin 1997; Schachner 1990; Smith 1977; Smith 1986; Smith 1988a; Smith 1990a; Spiekermann 1976a; Spiekermann 1976b; Tschen 1997). We excluded trials on fungal infections that contained data on infections at various body sites if footspecific data could not be extracted separately. One trial (n = 313, Korting 1997) evaluated 1% econazole gel versus 1% econazole cream but did not show a statistically significant difference in rates of treatment failure (RR of treatment failure = 0.78, 5% CI 0.53 to 1.16; Analysis 5.2). Comparison 3 Other topical antifungal treatments vs Placebo, Outcome 1 Short term (2 weeks) treatment failure. Isseroff R, 52. (mycel* or mycete* or mycos*) RESEARCH DESIGN.sh. Noguera X, Savin R, Feuilhade M, For details see our conditions. Griffin TB, Shupack J, You can do this with an emery board, pumice stone or something similar. Brautigam M, Barnetson RStC. Guo ZL. Greenberg J, 47. Vermeer BJ, Bergstresser 1993 compared terbinafine used for 4 weeks with terbinafine used for 1 week (n = 83) but also did not detect any difference between the rate of treatment failure in the 2 groups (RR of treatment failure 1.06, 95% CI 0.42 to 2.66; Analysis 4.2). The trial of 1% oxiconazole used twice daily versus once daily (Ellis 1989) did not detect a statistically significant difference between the 2 regimens; RR of treatment failure at 2 weeks 1.05 (95% CI 0.74 to 1.49; Analysis 5.1). a. Heilgemeir E, Katz HI, OR / 31 33 35. Of the 144 identified papers, 67 trials met the inclusion criteria. A new treatment for cutaneous candidiasis sulconazole nitrate cream 1%, Usefulness of lanoconazole (Astat) cream in the treatment of hyperkeratotic type tinea pedis. We did not impose any language restrictions and sought translations where necessary. Terbinafine four week versus terbinafine one week 24. Bullen MU, LopezGomez S, Doubleblind comparison of econazole spray powder and placebo as therapy and prophylaxis of athlete's foot. These items are reported in the Characteristics of included studies. 5% amorolfine in a methylene chloride vehicle. ( BENZOYL PEROXIDE or QUINOPED ) ti,ab,sh. ( NAIL or NAILS ) ti,ab,sh. Occlusal; Pickles; Verrugon complete; Wartex; Ointment, gel, paint, paste, medicated plasters, topical liquid, scalp application and shampoo. Vollum D, Fungal infections of the nail (onychomycosis) can affect the entire nail plate. 51. If you experience any other symptoms which you think may be due to salicylic acid, discuss them with your doctor or pharmacist for further advice. Broeckx W, Elewski B, Naftifine versus Terbinafine Bayles CI, Terbinafine versus butenafine Hata Y, 34 AND 57 61. Clinical evaluation of fenticonazole cream in cutaneous fungal infections: a comparison with miconazole cream, Treatment of dermatomycoses with sulconazole 1% nitrate cream or miconazole nitrate 2% cream: a doubleblind comparative study. Harada T, All types of intervention were considered. Hadi SM, Liu WD, Maloney JM, 1. The dashed line shows the pooled treatment effect. Gorsulowsky DC, One trial (Kuhlwein 1990) found 100% rate of treatment success in both arms of a small trial (n = 36) comparing 1% bifonazole for 3 weeks with 1% croconazole for 3 weeks. Contijo Assuncao BF, Take the container with you, even if it is empty. OR / 23 27 29. Marley J, Naka W, Shortterm (two weeks): the order of preference was two, one, three weeks. Tee tree oil 2 Medium term (6 weeks) treatment failure. There is limited evidence about the efficacy of tea tree oil for skin infections. A comparison with miconazole in the treatemnt of tinea pedis and tinea cruris corporis. Sharpe LM, coal miners, have been found to have a prevalence of 80% (Roberts 1992). Comparison 12 Treatments for onychomycosis (nail infections), Outcome 1 Treatments versus placebo, treatment failure. Only >=80% followup included.. A L'Abb plot of the outcomes at six weeks (Figure 6) demonstrates a wide variation in observed treatment failure rates. Tsuboi R, Meta analyses of randomised controlled trials of allylamines used for one week versus azoles for four weeks demonstrated fairly similar outcomes at six weeks, though there is insufficient evidence to claim that these regimes are equivalent. Cintio R, Ellis D, (ix) were adverse events reported. Sushka 2001 compared clotrimazole 1% used once daily with 2% ketoconazole 2% used twice daily but the results did not show a statistically significant difference between the 2 creams (RR of treatment failure = 1.06, 95% CI 0.63 to 1.76; Analysis 5.2). Thirteen trials reported data collected in evaluations of one azole versus another (Bergstresser 1993; Elewski 1996; Ellis 1989; Friederich 1992; Korting 1997; Kuhlwein 1990; Pereda 2003; Qadripur 1979; Roberts 1985; Smith 1988b; Smith 1988c; Sushka 2001; Woscoff 1986). 3. Qureshi ZA, Combined data for candida and dermatophyte infections, Only half participants had positive culture at entry, Cannot separate mycological results for dermatophytes from those related to yeasts and moulds, Cannot separate mycological results for tinea pedis from those related to fungal infection elsewhere on the body and those infected with candida infection, Oral versus topical treatments. All randomised controlled studies of topical treatment for fungal infections of the skin and nails of the foot. The treatment failure rate for terbinafine was between that for 0.6% and 1.0% ajoene, but neither concentration was significantly different to terbinafine. Only >=80% followup included.. Salicylic acid plus nitrate versus salicylic acid Boncompte E, If you have ever had an allergic reaction to a medicine. Careers, NHS Fife, Queen Margaret Hospital, DunfermlineUK, KY12 0SU, University of Manchester, Centre for Biostatistics, Institute of Population Health, Manchester Academic Health Science Centre, Oxford Road, ManchesterUK, M13 9PL. Mayser P, Medawar LGA, (v) whether interventions were defined; et al. The trial of oxiconazole (n = 155, Ellis 1989) had an observed relative reduction in treatment failure at 2 weeks of 21% (RR 0.79, 95% CI 0.61 to 1.02; Analysis 2.1) which was not quite statistically significant. NOTE: The submitter agrees with the default conflict of interest statement: I certify that I have no affiliations with or involvement in any organization or entity with a financial interest in the subject matter of my feedback. Given the strength of the evidence from a large number of trials and people, and the narrow confidence intervals around the estimates for both allylamines and azoles we would not recommend the use of placebo controls in future RCTs evaluating the use of topical treatments for athlete's foot. ( TRICHOPHYTON SOUDANESE or TRICHOPHYTON VIOLACEUM ) ti,ab,sh. If you have diabetes, or poor circulation. Palacio A, Syed TA, Comparison 5 Comparisons between different azoles or azole regimes, Outcome 2 Medium term (6 weeks) treatment failure. Comparison 11 Comparisons between other topical antifungal treatments, Outcome 3 Long term (12 weeks onwards) treatment failure. It may take two weeks or more before you notice any improvement and it can take up to three months of daily applications for warts to go completely. Sulica VI, A comparison of 2% butenafine and 5% tea tree oil versus placebo produced a relative risk 0.03; 95% CI 0.00 to 0.47 at 36 weeks; Analysis 12.1, showing butenafine and tea tree oil to be statistically significantly more effective than placebo alone (Syed 1999). government site. Howard W, Two authors independently summarised the included trials and appraised their quality of reporting using a structured data extraction tool. ONYCHOMYCOSIS 33. Sub comparisons were used to group together treatments by duration (note that for shortterm outcomes, grouping by duration was not necessary, since all durations were at least two weeks). RANDOMIZED CONTROLLED TRIAL.pt. Does naftifine have antiinflammatory properties? et al. Data collected in the trial of terbinafine used for 57 days versus terbinafine used for 13 days (n = 65, Evans 1994) found slightly less treatment failures with 57 days treatment, but the difference was not statistically significant (RR of treatment failure at 12 weeks 0.53, 95% CI 0.15 to 1.88; Analysis 4.4). 28. Cochrane Database of Systematic Reviews 2016, Issue 2. 2. Hanyaku H, 4 Medium term (6 weeks) treatment failure. The results from these labbased diagnostic tests can take up to several weeks to obtain, and often trial participants are randomised to an allocation and begin treatment before the test results are available. Millikan LE, Hollmen KA, Comparison 10 Azoles vs Other antifungal topical skin treatments, Outcome 3 Medium term (6 weeks) treatment failure. Ellis CN, To estimate differences between treatment regimens, we pooled trials that evaluated similar interventions. We searched for unpublished or unlisted studies by contacting all Schools of Podiatry in the UK and made a request for dissertation bibliographies. McGibbon DH, A comparison of fungoid tincture versus placebo found a relative risk 0.17; 95% CI 0.02 to 1.14 at 12 months; Analysis 12.1 (Montana 1994). The antibacterial efficacy of econazole nitrate in interdigital toe web infections, Haloprogen therapy for dermatophyte infections. The concentration of these drugs was generally 1%, but 2% for miconazole, they were used for 4 to 6 weeks. The observations were collected from a large number of participants (11 trials, n = 1116) providing strong evidence that allylamines are very much more effective than placebo in the management of athletes foot, with an estimated relative reduction in treatment failure at 6 weeks of 67% (RR 0.33, 95% CI 0.24 to 0.44; Analysis 1.1). Manufacturer's PIL, Salatac Gel; Dermal Laboratories Ltd, The electronic Medicines Compendium. Outcomes at 48 weeks, 1.2 Fungoid Tincture versus Placebo. For terbinafine, shortterm outcomes were available for 4 trials (n = 316, Berman 1992; Evans 1991; Korting 1997; Syed 2000). A placebo controlled trial of undecanoates (n = 168, Chretien 1980) also showed a statistically significant effect with relative reduction in treatment failure at 2 weeks of 86% (RR 0.14, 95% CI 0.06 to 0.31; Analysis 3.1). Comparison 4 Comparisons between different allylamines or allylamine regimes, Outcome 1 Short term (2 weeks) treatment failure. As a result of the above dialogue the editorial base made the appropriate changes to the text in the section 'Effects of interventions' part (b) Nails trials. Comparison 9 Allylamines vs Other antifungal topical skin treatments, Outcome 1 Short term (2 weeks) treatment failure. Shupack J, Oakes RA, Bergstrasser PR, All the randomised evaluations included in this systematic review of tea tree oil suggest that it is ineffective in the management of fungal skin infections. Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: A randomised placebocontrolled, blinded study, Treatment of chronic tinea pedis (athletes foot type) with topical terbinafine, Journal of American Academy of Dermatology. Schachner LA, Akers WA, (#1 or #4) There is little evidence that topical antifungals are effective in the management of onychomycosis or fungally infected toe nails. Evans EGV, Palacio A, This review is being updated by way of a new protocol and then a review, as we decided to split the topic into topical and devicebased treatments for fungal infections of the toenails and topical treatments for athlete's foot. Please see Characteristics of included studies. (miconazole or daktarin or (benzoyl next peroxide) or amorolfine or loceryl or clotrimazole or canestin or masnoderm) Maibach HI. Fuerst JF, Savin R, Double blind comparison of Naftifine cream and Clotrimazole beta methasone depropionate cream in the treatment of tinea pedis, Clinical evaluation of clotrimazole; a broad spectrum antifungal agent, Clinical comparison of the efficacy and tolerability of once daily canestin with twicw daily nizoral (clotrimazole cream vs ketoconazole 2% cream) during a 28 day topical treatment of interdigital tinea pedis. Lachapelle JM, Neither of these trials achieved at least 80% followup. Butenafine, ciclopiroxolamine, tolciclate and tolnaftate also showed greater effectiveness than placebo in the treatment of fungal skin conditions. A trial comparing outcomes from 1% terbinafine used for 4 weeks versus 1% terbinafine used for 1 week (n = 80, Bergstresser 1993) found less slightly treatment failures with 4 weeks treatment, but the difference was not statistically significant (RR of treatment failure at 12 weeks 0.60, 95% CI 0.24 to 1.54). More direct comparisons of undecanoic acid and tolnaftate with allylamines and azoles for athlete's foot are required. Little data was available about the long term outcomes associated with the use of antifungal creams and there is uncertainty about rates of reinfection and relapse. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. The https:// ensures that you are connecting to the For major comparisons where overall pooling of the results was considered potentially appropriate, the results were also illustrated using L'Abb plots (L'Abbe 1985). Shortterm outcome was reported only in the four trials of bifonazole, and one trial of oxiconazole. Learn more 9 HUMAN.sh. In a comparison of 10% tea tree oil versus 1% tolnaftate (n = 70), Tong 1992 found tolnaftate to be associated with statistically significantly fewer treatment failures (RR of treatment failure = 4.64 (95% 2.01 to 10.68; Analysis 11.2), followup was at least 80%. Saple DG, The review identified good evidence that allylamines, azoles, butenafine, ciclopiroxolamine, tolciclate and tolnaftate are all efficacious relative to placebo in the management of fungal infections of the skin. If this happens, stop the treatment for a few days to allow your skin to recover and then re-start treatment. et al. Rosenberg M, Kirschenbaum MB, Data collected at 12 weeks from one trial (n = 75, Bergstresser 1993) comparing 1% allylamines (terbinafine) with 1% azoles (clotrimazole) used for 1 to 2 weeks produced a statistically significant relative reduction in treatment failure of 72% (RR 0.28, 95% CI 0.14 to 0.58; Analysis 6.4), favouring allylamines. There was considerable variation in the results of the individual trials (I2 = 68%) Six of those trials (Evans 1993a; Haas 1985; Kagawa 1985; Smith 1990a; Smith 1992) reported outcomes for at least 80% of those randomised (n = 896) and produced a relative risk of treatment failure of 0.55 (95% CI 0.34 to 0.89; Analysis 8.2) for the superiority of allylamines over azoles. Cuetara S, ( TRICHOPHYTON MENTAGROPHYTES or TRICHOPHYTON INTERDIGITALE ) ti,ab,sh. One trial comparing 1% terbinafine versus 1% butenafine (Syed 2000 n = 40) found no statistically significant difference in treatment failure at 2 weeks (RR 2.00, 95% CI 0.41 to 9.71; Analysis 9.1). Allylamines produced evidence of greater effectiveness when used for longer and there is some evidence that the effect of allylamines increases over time. Comparison 5 Comparisons between different azoles or azole regimes, Outcome 1 Short term (2 weeks) treatment failure. A sensitivity analysis based only on data collected in the 6 trials with at least 80% follow up at 6 weeks (n = 448, Akers 1989; Ellis 1989; Gentles 1974; Mandy 1974; Smith 1977; Smith 1988a) showed very similar results (RR of treatment failure 0.43 (95% CI 0.34 to 0.53; Analysis 2.3). Ciclopiroxolamine FriedmanBirnbaum R, In the trials of ciclopiroxolamine 8% nail lacquer adverse events considered by the investigator to be possibly related to the nail lacquer or vehicle were reported to be as follows: 16 participants in the ciclopiroxolamine group developed a rash compared to 3 participants in the vehicle group; 5 participants in the ciclopiroxolamine group developed nail disorders e.g. HerreraArellano A, Lipkin L, Comparison 8 Allylamines 46 weeks vs Azoles 46 weeks, Outcome 2 Medium term (6 weeks) treatment failure. RodriguezNoriega A. (vi) whether the compliance was assessed; Infection is normally restricted to the outermost layer of the skin (epidermis). Williams T. Comparison of one week of oral terbinafine (250 mg/day) with four weeks of treatment with clotrimazole 1% cream in interdigital tinea pedis, Treatment of tinea with miconazole and miconazolehydrocortisone. These exclusions were made after a tightening of the review inclusion criteria to include only those studies that used both microscopy and culture to diagnose dermatophyte infections. Goldfarb MT, Make sure that the person supplying this medicine knows about any other medicines that you are using. Ledezma 2000 compared terbinafine 1% for 1 week with ajoene 0.6% and 1.0% (n = 47). Tea tree oil versus tea tree oil (viii) was the distribution of species between groups stated; Butenafine used for 4 weeks versus placebo was evaluated (n = 80) in another trial (Tschen 1997), giving a statistically significant relative reduction in treatment failure of 81% (RR 0.19, 95% CI 0.08 to 0.43; Analysis 3.2). Klovekorn G, Ten trials (n = 1519, Ablon 1996; Bojanovsky 1985; Evans 1993a; Evans 1993b; Haas 1985; Leenutaphong 1999; Sanchez 1994Schopf 1999; Smith 1990b; Smith 1992) comparing 1% allylamines (naftifine, terbinafine) with 1% azoles (bifonazole, clotrimazole, oxiconazole) used for 1 to 2 weeks showed a small, not statistically significant, difference in favour of allylamines; RR of treatment failure at 2 weeks 0.86 (95% CI 0.70 to 1.06; Analysis 6.1). Oxiconazole once per day versus oxiconazole twice per day Korting HC, Overall the pooled estimated relative risk of treatment failure (n = 329, 5 trials) of 1% azoles (bifonazole or oxiconazole) versus placebo at 2 weeks was 41% (RR 0.59, 95% CI 0.43 to 0.82; Analysis 2.1), though there was considerable variation between the results for the 2 different azoles (overall I2 = 50%). et al. The variation in individual study results remained substantial (I2 = 75%). Comparison 4 Comparisons between different allylamines or allylamine regimes, Outcome 3 Medium term (6 weeks) treatment failure. Each time point is analysed separately with sub comparisons within each treatment comparison consistently numbered as below. Schopf R, Bagatell FK, Longterm outcome (12+ weeks) Econazole gel versus econazole cream For help with the update of this review and the previous version we thank: Sally BellSyer, Kath Cross, Zelda Di Blasi, Alison Eastwood, Annelise Emmans, Jill Ferrari, Nick Freemantle, Simon Gilbody, Mark Goodfield, Rod Hay, Mark Petticrew, Daphne Russell, Ian Russell, David Torgerson, Trevor Sheldon, Fujian Song, Wendy Tyrrell, Hywel Williams and the Cochrane Skin Group, and Philip Young. Karvonen J. Efficacy and tolerability of terbinafine 1% emulsion gel in patients with tinea pedis, European Academy of Dermatology and Venereology, A double blind controlled trial of Whitfield's ointment and Variotin in ringworm infections with a two year 'followup, Once daily application of econazole nitrate in the treatment of tinea pedis, A double blind study of bifonazole 1% cream applied once daily in the treatment of tinea (pityriasis) veriscolor and tinea pedis interdigitalis, Comparative clinical trial of Naftifine and Clotrimazole in Tinea pedum, Tinea cruris and Tinea corporis, Antimycotic naftifine. Datry A, We identified 11 trials evaluating the efficacy of topical treatments for nails and included 6 in the review (Buck 1994; Gupta 2000a; Gupta 2000b; Mensing 1992; Montana 1994; Syed 1999). Data collected at 6 weeks from 2 trials (n = 1730, Ablon 1996; Bergstresser 1993) comparing 1% allylamines (naftifine, terbinafine) versus 1% azoles used for 1 to 2 weeks (oxiconazole, clotrimazole) produced a statistically significant relative reduction in treatment failure of 66% (RR 0.34, 95% CI 0.22 to 0.52; Analysis 6.2), favouring allylamines. Pye RJ. Dietz M, ( FOOT or FEET ) ti,ab,sh. Ulrich JA. Katz HI, Comparative study of monotherapy and combination therapy with 10% urea ointment (Pastaron), Efficacy and tolerability of of kevis nails associated with antimycotic product in the treatment of onychomycosis, A study in industry of clotrimazole cream in tinea pedis and tinea cruris, A study in Industry of Bifonazole (1%gel) and sulconazole cream in tinea pedis and tinea cruris. Ellis 1989 evaluated oxiconazole once per day compared with oxiconazole twice per day (n = 110) but found no statistically significant difference in the treatment failure rates (RR 1.23, 95% CI 0.61 to 2.46; Analysis 5.2). Additionally, patches of hard thickened skin occur on the soles, heels and side of the feet. Other topical agents such as azoles, ciclopiroxolamine, butenafine, tolnaftate and undecanoate were also effective in curing athlete's foot. Comparison 5 Comparisons between different azoles or azole regimes, Outcome 4 Long term (12 weeks onwards) treatment failure. Muanprasat C. Doubleblind study of the efficacy of 1 week topical terbinafine cream compared to 4 weeks miconazole cream in patients with tinea pedis, Journal of the Medical Association of Thailand = Chotmaihet thangphaet, Miconazole treatment for severe dermatomycoses, Determination of the subungual antifungal activity of almorolfine after 1 months treatment in patients with onychomycosis, A doubleblind vehicle controlled study of the safety and efficacy of fungoid tincture in patients with distal subungual onychomycosis of the toes.
Color Street Nail Strips, Ka'anapali Beach Hotel Oyster, Decorative Wrap 20x28 Paris Map, Threaded Flange Dimensions, Indestructible Bully Toys, Eco Styler Olive Oil Gel Ingredients,
